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Figure 4
The EcFtsZ(L178E) structure adopts the R state. (a) Superimposition of the EcFtsZ(L178E) structure (red) onto the R-state S. aureus FtsZ structure (PDB entry 1ofu; cyan). (b) Overlay of the EcFtsZ(L178E) structure (red) onto the T-state S. aureus FtsZ structure (PDB entry 3voa; green). (c) Overlay of the EcFtsZ(L178E) N-terminal subdomain (red) onto the N-terminal subdomain of the T-state structure (PDB entry 3voa; yellow), showing that the N-terminal subdomains adopt the same conformations in R and T states. (d) Superimposition of the C-terminal subdomain of EcFtsZ(L178E) (red) onto the C-terminal subdomain of the R-state FtsZ structures (PDB entry 3wgl, magenta; PDB entry 1ofu, cyan), showing they have the same general fold (r.m.s.d.s of 1.1 and 0.8 Å, respectively). (e) Superimposition of the EcFtsZ(L178E) C-terminal subdomain (red) onto the C-terminal subdomains of the T-state FtsZ structures (PDB entry 4dxd, cyan; PDB entry 3voa, magenta), showing that the EcFtsZ (R-state) C-terminal subdomain has structural differences compared with T-state C-terminal subdomains (both r.m.s.d.s are >2 Å). |
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