Structure of cyclin-dependent kinase 2 (CDK2) in complex with the specific and potent inhibitor CVT-313

Talapati, S.R.; Nataraj, V.; Pothuganti, M.; Gore, S.; Ramachandra, M.; Antony, T.; More, S.S.; Krishnamurthy, N.R.

doi:10.1107/S2053230X20009243

Acta Crystallographica Section F
Acta Crystallographica
Section F STRUCTURAL BIOLOGY COMMUNICATIONS

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Figure 6
(a) DFG-in conformation of the CDK2–CVT-313 complex with Phe146 in the hydrophobic pocket. (b) DFG-out conformation of the CDK2–K03861 complex with Phe146 moved away from the hydrophobic pocket.

STRUCTURAL BIOLOGY
COMMUNICATIONS

ISSN: 2053-230X

Volume 76| Part 8| August 2020| Pages 350-356

https://doi.org/10.1107/S2053230X20009243

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