Figure 1
Schematic domain structures of chicken FANCM, MHF1 and MHF2. FANCM has an SF2 helicase domain at the N-terminus followed by an MHF interaction domain and an ERCC4 nuclease-like domain at the C-terminus. MHF binding indicates an interface with MHF. MHF is composed of MHF1 and MHF2, both of which contain a histone fold (HF). MHF1 contains an additional intrinsically disordered region. For crystallization and biochemical analysis, MHF1 was truncated at Glu106. |