Figure 3
Crystal structures of MHF and FANCM–MHF. (a, b, d) Crystal structures of (a) MHF from the crystal in Fig. 2(b), (b) MHF from the crystals in Fig. 2(c) and (d) FANCM–MHF from the crystal in Fig. 2(a). MHF1, MHF2 and FANCM are colored cyan, magenta and black, respectively. The crystallographic symmetry heterodimer is colored in transparent mode in (a). N and C indicate the N- and C-termini of FANCM in (d). (c) Superimposition of three MHF tetramers from (a) in blue, (b) in red and PDB entry 3b0b in gray. One of the MHF1 α4 helices in (b) deviates from the others by 23°. |