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Figure 3
(a) Overall structure of the HsCRM1–HsRanGTP–BME complex depicted in cartoon representation. CRM1 is shown in light blue and Ran is colored red. The BME–Cys528 covalent adduct, located in the NES-binding cleft, is represented as spheres. Structural alignment of the BME-bound cleft with the unliganded cleft (yellow; PDB entry 3m1i; Koyama & Matsuura, 2010BB27) is shown in (b), with LMB-bound CRM1 (pale green; PDB entry 6tvo; Shaikhqasem et al., 2020BB43) in (c) and with NES-bound CRM1 (salmon; PDB entry 3nby; Güttler et al., 2010BB15) in (d). BME is not shown in (b) and is depicted as sticks in (c) and in (d). LMB is depicted as sticks (pale green) in (c).

Journal logoSTRUCTURAL BIOLOGY
COMMUNICATIONS
ISSN: 2053-230X
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