issue contents
March 2021 issue
research communications
Structural comparison of the apo form of Saccharomyces cerevisiae anthranilate phosphoribosyltransferase with structures of its complexes with PRPP or the substrate analogue 4-fluoroanthranilate provide structural insights into substrate binding.
Open access
The covalent modification of human CRM1 by 2-mercaptoethanol interferes with the characterization of cysteine-dependent inhibitor compounds.
PDB reference: human CRM1 covalently modified by 2-mercaptoethanol, 7b51
The isolated complex of the TF55β chaperonin from the thermophilic archaeon Sulfolobus solfataricus are reported. The structures of nucleotide-bound complexes of TF55β obtained at 3.6–4.2 Å resolution using cryo-EM reveal an open conformation.
Cadherin-17, a 7D-cadherin, has N-terminal extracellular cadherin (EC) repeats similar to those of classical cadherins but with several key differences that are relevant to its biological function. The structure presented here demonstrates that cadherin-17 is incapable of forming the EC1 tryptophan-mediated strand-swap conformation that classical cadherins use to adhere cells together.
PDB reference: human CDH17 EC1–2, 6ulm