Figure 3
Structural comparison of loop regions at the top of the Vap β-barrel. An all-against-all analysis was performed with the DALI server (Holm, 2020) for truncated Vap structures, in which flexible (N- and C-termini) or variable (β2–β3 loop) residues had been removed. These six truncated Vap structures correspond to VapB residues 89–108 and 113–192. (a) Heat map of pairwise Z-scores. The bar on the right assigns colours to Z-scores. The pairwise root-mean-square distances (r.m.s.d.s) are given in Supplementary Table S1. (b) VapD and the open VapB structure appear as outliers in correspondence analysis, a multidimensional scaling method that positions data points with the most similar structural neighbourhoods near each other. The horizontal and vertical axes represent the first and the second eigenvector, respectively. |