Figure 2
Protein sequences and structural comparisons of the TLDc domains. (a) The multiple sequence alignment was performed with ENDscript (Robert & Gouet, 2014) and adjusted manually. The secondary structures (α, α-helix; β, β-strand, η, 310-helix; TT, turn) of the three TLDc structures extracted from the crystal structures are indicated above the alignment. The green spheres below the alignment indicate the position of missense mutations that are found in the TLDc domain of TBC1D24 and are associated with human diseases. (b) Structural comparison of the three TLDc domains from D. rerio (PDB entry 4acj; left; brown), H. sapiens (PDB entry 7obp; middle; blue) and D. melanogaster (PDB entry 6r82; right; red). |