Structures of the Plasmodium falciparum heat-shock protein 70-x ATPase domain in complex with chemical fragments identify conserved and unique binding sites

Mohamad, N.; O'Donoghue, A.; Kantsadi, A.L.; Vakonakis, I.

doi:10.1107/S2053230X21007378

Acta Crystallographica Section F
Acta Crystallographica
Section F STRUCTURAL BIOLOGY COMMUNICATIONS

IUCr IT WDC

home archive editors for authors for readers submit subscribe open access

view article

Figure 2
Analysis of interaction site 1. (a) Surface representation of the PfHsp70-x site 1, with ligands binding to this site shown as sticks. Site 1 is subdivided into three areas (subsites A and B and the `bridge'). (b–d) Detailed views of the three subsites. In each case the fragment ligand and protein amino acids within 4 Å are shown, with the exception of Thr111 (b), which is located 5 Å from the ligand. Amino-acid residues that differ between PfHsp70-x and the human erythrocytic chaperones are labelled. Yellow dashed lines indicate hydrogen bonds inferred from the structure.

STRUCTURAL BIOLOGY
COMMUNICATIONS

ISSN: 2053-230X

Volume 77| Part 8| August 2021| Pages 262-268

https://doi.org/10.1107/S2053230X21007378

Open

access

Follow Acta Cryst. F

Search IUCr Journals		doi		Advanced search
Author		volume	page