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Figure 5
A side-by-side comparison of the primarily polar interactions of OXA-436 (green, middle) and OXA-48 (cyan, right) with the substrates ampicillin, imipenem and meropenem inferred from molecular-dynamics simulations of the acyl complexes reveals differences in preferred binding modes. For each substrate, the molecular structure of the intact antibiotic is shown above the name (left). For meropenem, the tertiary amide in the model with OXA-48 is hidden behind the R2 substituent carbonyl.

Journal logoSTRUCTURAL BIOLOGY
COMMUNICATIONS
ISSN: 2053-230X
Volume 77| Part 9| September 2021| Pages 312-318
https://doi.org/10.1107/S2053230X21008645
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