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Figure 5
Inhibition of hCA II by carboxylic acid compounds. Inhibition constants previously reported as IC50, Ki or Kd versus active-site distance. Direct binders are shown as blue circles and indirect binders as red squares. For direct binders the distance from the zinc to the closest O atom in the carboxyl group is measured, while for indirect binders the distance from the ZBS to the zinc is measured.

Journal logoSTRUCTURAL BIOLOGY
COMMUNICATIONS
ISSN: 2053-230X
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