Crystal structure of the capsular polysaccharide-synthesis enzyme CapG from Staphylococcus aureus

The crystal structure of CapG from Staphylococcus aureus (SaCapG) forms a homohexamer, in contrast to the dimeric or tetrameric assembly of its bacterial homologues. The conformational flexibility of α2, the α2–α3 loop and α10 of SaCapG probably facilitates the binding of substrates and/or the release of products.

Crystals of SctV from different species reveal variable symmetry for the cytosolic domain of the type III secretion system export gate

Three crystal forms of the type III secretion system export-gate protein SctV from two bacterial species reveal different cyclic oligomers, namely an octamer, a nonamer and a decamer.

Ibuprofen: a weak inhibitor of carbonic anhydrase II

The X-ray crystal structure of ibuprofen (a common nonsteroidal anti-inflammatory drug) in complex with the zinc metalloenzyme human carbonic anhydrase II (hCA II) is reported. In addition, the hCA II inhibition profiles of ibuprofen and other carboxylic acid-based compounds are presented and discussed.