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February 2024 issue
Cover illustration: The RNA-recognition motif of Drosophila melanogaster tRNA (uracil-5-)-methyltransferase homolog A (TRMT2A) [Witzenberger et al. (2024), Acta Cryst. F80, 36–42]. Human TRMT2A has been described as a modifier of polyglutamine (polyQ)-derived neuronal toxicity which is implicated in Huntington's disease and other devastating neurodegenerative diseases. In polyQ disease models, silencing of TRMT2A reduced polyQ-associated cell death and polyQ protein aggregation, suggesting this protein as a valid drug target. The 1.6 Å resolution crystal structure of the RNA-recognition motif (RRM) from D. melanogaster, which is a homolog of human TRMT2A, has been described and analysed.
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Acta Cryst. F – Structural Biology Communications plans to introduce more video content to articles and Dialpuri et al. [(2024). Acta Cryst. F80, 30–35] provide an early example.
methods communications
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The Privateer carbohydrate 3D structure-validation software is now freely available as a web app. Here, its use is described, including a practical example.
research communications
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The 1.6 Å resolution crystal structure of the RNA-recognition motif of D. melanogaster tRNA (uracil-5-)-methyltransferase homolog A is reported.
PDB reference: RNA-recognition motif of TRMT2A, 7pv5
Three structure determinations of Mycobacterium paratuberculosis and Burkholderia thailandensis IspD are reported (PDB entries 7kmw, 4zdq and 4ys8). In addition, the biophysical characterization of the enzymes and the binding affinity of the B. thailandensis enzyme in complex with cytidine triphosphate are reported.
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