Ternary structure of Plasmodium vivax N-myristoyltransferase with myristoyl-CoA and inhibitor IMP-0001173

Bolling, C.; Mendez, A.; Taylor, S.; Makumire, S.; Reers, A.; Zigweid, R.; Subramanian, S.; Dranow, D.M.; Staker, B.; Edwards, T.E.; Tate, E.W.; Bell, A.S.; Myler, P.J.; Asojo, O.A.; Chakafana, G.

doi:10.1107/S2053230X24008604

Acta Crystallographica Section F
Acta Crystallographica
Section F STRUCTURAL BIOLOGY COMMUNICATIONS

IUCr IT WDC

home archive editors for authors for readers submit subscribe open access

view article

Figure 1
PvNMT structure. (a) There are two PvNMT monomers in the asymmetric unit. Chain A (gray) has a bound Myr-CoA (green sticks) and inhibitor IMP-0001173 (blue sticks). Chain B (pink) shows a PvNMT monomer in the apo state. (b) Cartoon of PvNMT monomer A colored in a rainbow from blue at the N-terminus to red at the C-terminus. Myr-CoA (magenta sticks) and the inhibitor IMP-0001173 (white sticks) are shown. (c) Superposition of the monomers chain A (with ligands, gray) and chain B (apo PvNMT, pink). The substrate-binding cavity is indicated in purple parentheses, while the Myr-CoA-binding cavity is shown in black parentheses.

STRUCTURAL BIOLOGY
COMMUNICATIONS

ISSN: 2053-230X

Volume 80| Part 10| October 2024| Pages 269-277

https://doi.org/10.1107/S2053230X24008604

Open

access

Follow Acta Cryst. F

Search IUCr Journals		doi		Advanced search
Author		volume	page