Welcoming Alejandro Buschiazzo, Dorothee Liebschner and Stephen Muench as Co-editors of Acta Crystallographica F – Structural Biology Communications

The Section Editors welcome and introduce three new Co-editors to the journal and summarize their expertise in computational structural biology, experimental structural biology and cryo-electron microscopy.

Glucose-6-phosphate de­hydrogenase and its 3D structures from crystallography and electron cryo-microscopy

An investigation of different types of glucose-6-phosphate dehydrogenase (G6PD) is reported, including NAD⁺- and NADP⁺-dependent G6PDs, fused glucose-6-phosphate dehydrogenase–6-phosphogluconolactonase and bacterial F₄₂₀-dependent G6PD. An extensive data-review tabulation of PDB entries is also provided for both X-ray crystal and electron cryo-microscopy structures.

First crystal structure of the DUF2436 domain of virulence proteins from Porphyromonas gingivalis

The DUF2436 domain of unknown function is highly conserved in virulence proteins from the pathogenic oral bacterium P. gingivalis. Theis domain exhibits a noncanonical β-jelly-roll sandwich topology with a previously unobserved fold consisting of two antiparallel β-sheets and one short α-helix.

Protein expression, purification, crystallization and crystallographic studies of BPSL0741 from Burkholderia pseudomallei

The B. pseudomallei protein BPSL0741, which has previously been identified to be essential for survival of the bacterium in an infected host, was successfully overexpressed in its recombinant form and purified to homogeneity. The recombinant protein appeared to be monomeric in solution and the protein crystal diffracted to 2.1 Å resolution.

Ternary structure of Plasmodium vivax N-myristoyltransferase with myristoyl-CoA and inhibitor IMP-0001173

The 2.3 Å resolution ternary structure of the essential P. vivax N-myristoyltransferase with myristoyl-CoA and a peptide-binding domain inhibitor is reported as part of ongoing efforts by the SSGCID for the rational design of new therapeutics for malaria.

Crystal structure of guanosine 5′-monophosphate synthetase from the thermophilic bacterium Thermus thermophilus HB8

Guanosine 5′-monophosphate (GMP) synthetase (GuaA) catalyzes the last step of GMP synthesis in the purine nucleotide biosynthetic pathway. In this study, the crystal structure of an XMP-bound form of GuaA from the thermophilic bacterium T. thermophilus HB8 was determined at a resolution of 2.20 Å and that of an apo form was determined at 2.10 Å resolution.