Ternary structure of Plasmodium vivax N-myristoyltransferase with myristoyl-CoA and inhibitor IMP-0001173

Bolling, C.; Mendez, A.; Taylor, S.; Makumire, S.; Reers, A.; Zigweid, R.; Subramanian, S.; Dranow, D.M.; Staker, B.; Edwards, T.E.; Tate, E.W.; Bell, A.S.; Myler, P.J.; Asojo, O.A.; Chakafana, G.

doi:10.1107/S2053230X24008604

Acta Crystallographica Section F
Acta Crystallographica
Section F STRUCTURAL BIOLOGY COMMUNICATIONS

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Figure 4
LIGPLOT-generated interaction plots for PvNMT (PDB entry 6b1l) and HsNMT1 (PDB entry 5mu6) reveal (a) conserved Myr-CoA cavities and (b) differences in the peptide-binding cavity. The HsNMT1 structure (PDB entry 5mu6) has IMP-1088 within the peptide-binding pocket compared with IMP-0001173 in the PvNMT structure (PDB entry 6b1l).

STRUCTURAL BIOLOGY
COMMUNICATIONS

ISSN: 2053-230X

Volume 80| Part 10| October 2024| Pages 269-277

https://doi.org/10.1107/S2053230X24008604

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