Glucose-6-phosphate dehydrogenase and its 3D structures from crystallography and electron cryo-microscopy

Hanau, S.; Helliwell, J.R.

doi:10.1107/S2053230X24008112

Acta Crystallographica Section F
Acta Crystallographica
Section F STRUCTURAL BIOLOGY COMMUNICATIONS

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Figure 14
Proposed mechanism of the reaction catalyzed by FGD. An unknown base (:B) takes a proton from G6P, allowing hydride transfer to the F₄₂₀ cofactor and oxidation of glucose 6-phosphate to 6-phosphogluconolactone; Glu109 then releases a proton to form F₄₂₀H₂ (for details, see Oyugi et al., 2016

STRUCTURAL BIOLOGY
COMMUNICATIONS

ISSN: 2053-230X

Volume 80| Part 10| October 2024| Pages 236-251

https://doi.org/10.1107/S2053230X24008112

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