Figure 4
The highly conserved DUF2436 domain of PrtH and gingipains (Kgp and Rgp). (a) Domain organization of P. gingivalis strain 381 Kgp (UniProtKB ID P72194), P. gingivalis strain W50 Rgp (UniProtKB ID Q51839), P. gingivalis strain HG66 Kgp (UniProtKB ID P72197), P. gingivalis strain ATCC 33277 Kgp (UniProtKB ID B2RLK2), P. gingivalis strain W83 Kgp (UniProtKB ID Q51817) and P. gingivalis strain W83 PrtH (UniProtKB ID P46071). The DUF2436 domain is highlighted in a red box with white text. (b) A multiple sequence alignment of DUF2436 domains in PrtH and gingipains (Kgp and Rgp) reveals that the DUF2436 domain sequence is highly conserved across several strains. Notably, the first DUF2436 domain of W50 Rgp shows significant divergence from the conserved sequence (white background). The sequence alignments and analyses were performed using ClustalX (Larkin et al., 2007) and were visualized using GeneDoc (Nicholas et al., 1997). |