Structures of Trichomonas vaginalis macrophage migratory inhibitory factor

Srivastava, A.; Nair, A.; Dawson, O.C.O.; Gao, R.; Liu, L.; Craig, J.K.; Battaile, K.P.; Harmon, E.K.; Barrett, L.K.; Van Voorhis, W.C.; Subramanian, S.; Myler, P.J.; Lovell, S.; Asojo, O.A.; Darwiche, R.

doi:10.1107/S2053230X24011105

Acta Crystallographica Section F
Acta Crystallographica
Section F STRUCTURAL BIOLOGY COMMUNICATIONS

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Figure 2
Comparison with human MIF homologs. (a) His-TvMIF trimers (shown in gray) superpose well with each other and with hMIF-1 (PDB entry 1mif, shown in blue). (b) They also superpose well with hMIF-2 (PDB entry 3ker). All three structures reveal prototypical MIF trimers. (c) The additional residues in His-TvMIF occupy the location of the tautomerase inhibitor IPP (shown as golden sticks) in hMIF-2; further details of the N-terminus are shown in the enlarged red parentheses.

STRUCTURAL BIOLOGY
COMMUNICATIONS

ISSN: 2053-230X

Volume 80| Part 12| December 2024| Pages 341-347

https://doi.org/10.1107/S2053230X24011105

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