Structure of Plasmodium vivax N-myristoyltransferase with inhibitor IMP-1088: exploring an NMT inhibitor for antimalarial therapy

Mendez, A.; Bolling, C.; Taylor, S.; Makumire, S.; Staker, B.; Reers, A.; Hammerson, B.; Mayclin, S.J.; Abendroth, J.; Lorimer, D.D.; Edwards, T.E.; Tate, E.W.; Subramanian, S.; Bell, A.S.; Myler, P.J.; Asojo, O.A.; Chakafana, G.

doi:10.1107/S2053230X24011348

Acta Crystallographica Section F
Acta Crystallographica
Section F STRUCTURAL BIOLOGY COMMUNICATIONS

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Figure 3
Myr-CoA binding by NMTs. Conserved amino-acid residues mediate Myr-CoA binding in (a) PvNMT (PDB entry 5v0w), (b) HsNMT1 (PDB entry 5mu6) and (c) HsNMT2 (PDB entry 4c2x). This figure and other ligand-interaction figures were generated with LigPlus (https://www.ebi.ac.uk/thornton-srv/software/LigPlus/).

STRUCTURAL BIOLOGY
COMMUNICATIONS

ISSN: 2053-230X

Volume 81| Part 1| January 2025|

https://doi.org/10.1107/S2053230X24011348

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