Structure of Plasmodium vivax N-myristoyltransferase with inhibitor IMP-1088: exploring an NMT inhibitor for antimalarial therapy

Mendez, A.; Bolling, C.; Taylor, S.; Makumire, S.; Staker, B.; Reers, A.; Hammerson, B.; Mayclin, S.J.; Abendroth, J.; Lorimer, D.D.; Edwards, T.E.; Tate, E.W.; Subramanian, S.; Bell, A.S.; Myler, P.J.; Asojo, O.A.; Chakafana, G.

doi:10.1107/S2053230X24011348

Acta Crystallographica Section F
Acta Crystallographica
Section F STRUCTURAL BIOLOGY COMMUNICATIONS

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Figure 4
Comparison of inhibitor binding by NMTs. PvNMT interacts with IMP-1088 (PDB entry 5v0w) (a) with similar amino acids as HsNMT1 (PDB entry 5mu6) (b). Inhibitor IMP-1002 interacts with fewer amino acids on PvNMT (PDB entry 6mb1) (c), as does inhibitor DDD85646 with PvNMT (PDB entry 5g1z) (d).

STRUCTURAL BIOLOGY
COMMUNICATIONS

ISSN: 2053-230X

Volume 81| Part 1| January 2025|

https://doi.org/10.1107/S2053230X24011348

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