Structure of Plasmodium vivax N-myristoyltransferase with inhibitor IMP-1088: exploring an NMT inhibitor for antimalarial therapy

Mendez, A.; Bolling, C.; Taylor, S.; Makumire, S.; Staker, B.; Reers, A.; Hammerson, B.; Mayclin, S.J.; Abendroth, J.; Lorimer, D.D.; Edwards, T.E.; Tate, E.W.; Subramanian, S.; Bell, A.S.; Myler, P.J.; Asojo, O.A.; Chakafana, G.

doi:10.1107/S2053230X24011348

Acta Crystallographica Section F
Acta Crystallographica
Section F STRUCTURAL BIOLOGY COMMUNICATIONS

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Figure 5
Interactions in the peptide/substrate-binding cavity. (a) Interactions between HsNMT1 and a peptide inhibitor (GNCFSKPR; PDB entry 8q26). (b) The modeled superposed PvNMT structure (starting from PDB entry 5v0w with ligands removed) shows conserved interactions with the peptide inhibitor.

STRUCTURAL BIOLOGY
COMMUNICATIONS

ISSN: 2053-230X

Volume 81| Part 1| January 2025|

https://doi.org/10.1107/S2053230X24011348

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