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Figure 3
The dimeric interaction of the SsoGINS51A subdomains is incompatible with formation of the interaction with polymerase illustrated for TkGINS51B–RecJ–Pol. The GINS51B subunit (purple) of the TkGINS51B–RecJ–Pol structure (PDB entry 7e15; Oki et al., 2022BB32) was superimposed on one SsoGINS51B subdomain of the SsoGINS crystal structure to investigate the compatibility of similar interactions. Following this superposition, the RecJ subunit (salmon) did not clash with any component of SsoGINS, but the DNA polymerase II small subunit severely clashed with the dyad-related SsoGINS51B subunit. Hence, the SsoGINS51B dimeric interface is not compatible with simultaneous interaction with DNA polymerase in the fashion of TkGINS–RecJ–Pol. Superpositions and figures were prepared in PyMOL (Schrödinger).

Journal logoSTRUCTURAL BIOLOGY
COMMUNICATIONS
ISSN: 2053-230X
Volume 81| Part 5| May 2025| Pages 207-215
https://doi.org/10.1107/S2053230X25003085
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