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Figure 1
(a) IPP synthase reaction. (b) Rv2173 monomer (IPP-bound structure) with the core eight-helix bundle coloured blue and the additional helices in yellow. (c) Side (left) and top-down (right) views of the homodimer. Monomer 1 is coloured as in (b) and monomer 2 is in green with additional helices in orange. The metals from the IPP structure are shown as green spheres and the substrates IPP and DMAPP (from the superimposed DMAPP-bound structure) are shown as purple and pink sticks, respectively. |