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Figure 4
Overlay of the SAHA binding mode in CA II and the CA IX mimic. For reference, CA II is shown as a gray cartoon with the Zn2+ ion as a black sphere. SAHA and the hydrophobic residue 131 (Phe in CA II and Val in the CA IX mimic) for CA II and the CA IX mimic are shown in yellow and green ball-and-stick representation, respectively. This figure was generated using PyMOL v.2.5.2 (Schrödinger). |
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