Crystal structure of the folded domains of Xrs2 from Saccharomyces cerevisiae

Vigneswaran, A.; Shi, K.; Aihara, H.; Evans, R.L.; Latham, M.P.

doi:10.1107/S2053230X25006867

Acta Crystallographica Section F
Acta Crystallographica
Section F STRUCTURAL BIOLOGY COMMUNICATIONS

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Figure 5
Structural comparison of Sc Xrs2 and the TopBP1 BRCT7/8–BACH1 complex. (a) Structural overlay of the crystal structure of Sc Xrs2³²⁵ (colored as in Fig. 1

) with the TopBP1 BRCT7/8–BACH1 complex (teal and magenta; PDB entry 3al3; Leung et al., 2011

). (b) Detailed view of the BRCT 7/8 region of TopBP1 interacting with BACH1. (c) Detailed view of the BRCT1/2 region (yellow and blue) of Sc Xrs2³²⁵, with the BACH1 peptide (red) aligned to highlight the presence of numerous charged residues in Xrs2, suggesting a potential binding site for protein interactions.

STRUCTURAL BIOLOGY
COMMUNICATIONS

ISSN: 2053-230X

Volume 81| Part 9| September 2025| Pages 365-373

https://doi.org/10.1107/S2053230X25006867

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