 | Acta Crystallographica Section F Acta Crystallographica Section F STRUCTURAL BIOLOGY COMMUNICATIONS |
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![[Figure 3]](rf5050fig3mag.jpg)
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Figure 3
A first possible model for S100 disulfide-crosslinked homodimers. (a) Rosetta-based modeling of the S100A4 homodimer (PDB entry 2q91; Malashkevich et al., 2008  ) in the RAGE-bound S100A6 conformation yields a disulfide-crosslinked dimer through a Cys86–Cys86 linkage. The structure of the noncovalent S100A4 homodimer (PDB entry 2q91) is shown as light blue cartoon for comparison. (b) Rosetta-based modeling of an S100B homodimer (PDB entry 3d0y; Ostendorp et al., 2011) in the RAGE-bound S100A6 conformation yields a disulfide-crosslinked dimer through Cys85–Cys85 linkage. The structure of the noncovalent S100B homodimer (PDB entry 3d0y) is shown as a light green cartoon for comparison. (c, d) Zoom on the interface within the covalent S100A4 and S100B homodimers. In both cases, a network of aromatic and aliphatic residues on helices H1 and H4 maintains the interface through hydrophobic interactions. |
![[Figure 3]](rf5050fig3.jpg)
| STRUCTURAL BIOLOGY COMMUNICATIONS |
ISSN: 2053-230X
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