Crystal structure of tyrosine-tRNA synthetase from Helicobacter pylori G27

Igbalajobi, D.; Taylor, J.E.; Gao, R.; Ayanlade, J.; Zigweid, R.; Subramanian, S.; Udell, H.; Edwards, T.E.; Abendroth, J.; Lorimer, D.; Myler, P.J.; Staker, B.; Ndip, E.M.; Asojo, O.A.

doi:10.1107/S2053230X26010253

Figure 1
HpTyrRS structure. (a) HpTyrRS has a prototypical TyrRS topology (colored from blue at the N-terminus to red at the C-terminus). (b) ENDscript ribbon diagram. Ribbon thickness reflects secondary-structure similarity: thinner ribbons indicate more conserved regions and thicker ribbons suggest lower conservation, as determined by r.m.s.d. alignment of structures. The ribbon is colored by sequence identity (red = identical residues). (c) Solvent-accessible surface area of HpTyrRS colored by ENDscript sequence conservation, with identical residues colored red, reveals a large conserved central cavity. (d) SB-219383 in magenta sticks sits in the open central cavity in both SaTyrRS (blue) and HpTyrRS (gray). HpTyrRS (PDB entry 6byq) was aligned with SaTyrRS (PDB entry 1jii) within PyMOL to generate (d). (a)–(d) are in the same orientation. All figures were generated with PyMOL.

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ISSN: 2053-230X

Volume 82| Part 11| November 2026| Pages 369-375

https://doi.org/10.1107/S2053230X26010253

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