Crystal structure of tyrosine-tRNA synthetase from Helicobacter pylori G27

Igbalajobi, D.; Taylor, J.E.; Gao, R.; Ayanlade, J.; Zigweid, R.; Subramanian, S.; Udell, H.; Edwards, T.E.; Abendroth, J.; Lorimer, D.; Myler, P.J.; Staker, B.; Ndip, E.M.; Asojo, O.A.

doi:10.1107/S2053230X26010253

Figure 2
Superposed and modelled SB-219383 inhibitor binding. (a) HpTyrRS has conserved amino-acid residues in the superposed SB-219383 binding cavity. (b) SB-219383 (magenta) binds to SaTyrRS (blue) residues shown as blue sticks, as identified from PDB entry 1jii. (c) Superposed HpTyrRS (gray) and SaTyrRS (blue) reveal conserved amino acids. (d) Top docking pose of SB-219383 with HpTyrRS; docking score −8.03. (e) Top docking pose of SB-219383 with SaTyrRS; docking score −8.28. (f) CHEMDRAW representation of SB-219383. HpTyrRS (PDB entry 6byq) was superposed with SaTyrRS (PDB entry 1jii) within PyMOL to generate (a)–(c). (a)–(e) are in the same orientation as Fig. 1

and are magnified to visualize SB-219383. All figures were generated with PyMOL unless otherwise stated.

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Volume 82| Part 11| November 2026| Pages 369-375

https://doi.org/10.1107/S2053230X26010253

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