forthcoming articles

The following articles are a selection of those recently accepted for publication in Acta Crystallographica Section F: Structural Biology Communications.

See also Forthcoming articles in all IUCr journals.

Accepted 15 December 2024

Small-angle X-ray scattering of engineered antigen-binding fragments: the case of glycosylated Fab from the Mannitou IgM antibody

Shubham Semwal, Maria Karamolegkou, Stéphanie Flament, Nessim Raouraoua, Kenneth Verstraete, Aurélien Thureau, Frank Wien, Fabrice Bray, Savvas N. Savvides and Julie Bouckaert
This study provides a biochemical and biophysical analysis of Mannitou Fab, highlighting the intricate balance between stability, flexibility and function in engineered antibody fragments. The results underscore the critical role of glycosylation in modulating the oligomerization behaviour of Fab and preventing inappropriate intermolecular interactions, paving the way for more effective and reliable therapeutic antibodies in the future.
Accepted 11 December 2024

Co-crystal structure of Helicobacter pylori biotin protein ligase with biotinyl-5-ATP

Jesuferanmi P. Ayanlade, Dylan E. Davis, Sandhya Subramanian, David Dranow, Donald D. Lorimer, Brad Hammerson, Peter J. Myler and Oluwatoyin A. Asojo
Recombinant H. pylori biotin protein ligase was purified and its 2.25 Å resolution co-crystal structure with biotinyl-5-ATP is reported.


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