journal menuforthcoming articles
The following articles are a selection of those recently accepted for publication in Acta Crystallographica Section F: Structural Biology Communications.
See also Forthcoming articles in all IUCr journals.
research communications (RC)Structure of the Saccharolobus solfataricus GINS tetramer
Archaeal organisms possess Cdc45 and GINS homologs that are likely to serve similar functional roles, but their structural interactions with the MCM helicase and hence their mechanism of MCM activation are not as well understood as for their eukaryotic counterparts. We present the crystal structure of the S. solfataricus GINS tetrameric complex and illustrate that a subdomain would need to move to accommodate known archaeal GINS-complex interactions and to generate an S. solfataricus CMG complex analogous to that of eukaryotes.
research papersHigh-throughput protein crystallography to empower natural product-based drug discovery
High-throughput protein crystallography is used at the heart of a pipeline to accelerate the discovery of bioactive natural products by capturing hits directly from unpurified biota samples using protein crystals.
