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The following articles are a selection of those recently accepted for publication in Acta Crystallographica Section F: Structural Biology Communications.
See also Forthcoming articles in all IUCr journals.
research communications (RC)research communications (RC)X-ray structure of the human Nijmegen breakage syndrome forkhead-associated/BRCA1 C-terminal domain and computational docking of candidate radiosensitizers
Nijmegen breakage syndrome 1 (NBS1), a component of the MRE11–RAD50–NBS1 complex, plays a key role in the repair of DNA double-strand breaks. We report the first experimentally determined X-ray crystal structure of the FHA–BRCT region of human NBS1 and the results of docking simulations of candidate radiosensitizing compounds.
research communications (RC)Recombinant versus native botulinum neurotoxin type A: structural and pharmacodynamic comparison
For the first time, the recombinant core botulinum neurotoxin type A (BoNT/A) expressed in Escherichia coli and nicked in vitro is shown to be structurally identical to native BoNT/A from Clostridium botulinum, enabling direct activity comparison between the recombinant product and the native toxin.
research communications (RC)Crystal structure of the bifunctional enzyme phosphoribosyl isomerase A from Mycobacterium tuberculosis with bound light-controllable inhibitor
We have determined the crystal structure of an isomerase catalyzing two steps in histidine and tryptophan biosynthesis with a bound light-switchable competitive inhibitor. The work explains the mode of action of the inhibitor and describes the discovery of a hitherto unknown third phosphate-binding site of the enzyme.
