Structure of Plasmodium falciparum ADP-ribosylation factor 1

Cook, W.J.; Smith, C.D.; Senkovich, O.; Holder, A.A.; Chattopadhyay, D.

doi:10.1107/S1744309110036997

Structure of Plasmodium falciparum ADP-ribosylation factor 1

W. J. Cook, C. D. Smith, O. Senkovich, A. A. Holder and D. Chattopadhyay

Vesicular trafficking may play a crucial role in the pathogenesis and survival of the malaria parasite. ADP-ribosylation factors (ARFs) are among the major components of vesicular trafficking pathways in eukaryotes. The crystal structure of ARF1 GTPase from Plasmodium falciparum has been determined in the GDP-bound conformation at 2.5 Å resolution and is compared with the structures of mammalian ARF1s.

Keywords: ADP-ribosylation factors; protein trafficking; Plasmodium falciparum; malaria.

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Structure of Plasmodium falciparum ADP-ribosylation factor 1

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