Crystallization via tubing microfluidics permits both in situ and ex situ X-ray diffraction

Gerard, C.J.J.; Ferry, G.; Vuillard, L.M.; Boutin, J.A.; Chavas, L.M.G.; Huet, T.; Ferte, N.; Grossier, R.; Candoni, N.; Veesler, S.

doi:10.1107/S2053230X17013826

Crystallization via tubing microfluidics permits both in situ and ex situ X-ray diffraction

C. J. J. Gerard, G. Ferry, L. M. Vuillard, J. A. Boutin, L. M. G. Chavas, T. Huet, N. Ferte, R. Grossier, N. Candoni and S. Veesler

A microfluidic platform was used to address the problems of obtaining diffraction-quality crystals and crystal handling during transfer to the X-ray diffractometer. Crystallization conditions of a protein of pharmaceutical interest were optimized and X-ray data were collected both in situ and ex situ.

Keywords: crystallization; microfluidics; optimization; in situ X-ray diffraction; ex situ X-ray diffraction.

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Crystallization via tubing microfluidics permits both in situ and ex situ X-ray diffraction

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	Portable Document Format (PDF) file https://doi.org/10.1107/S2053230X17013826/ub5105sup1.pdf Supplementary Material.
	AVI file https://doi.org/10.1107/S2053230X17013826/ub5105sup2.avi Supplementary Video S1. Video showing placement of single crystals on the MicroMesh.