Nanoscopic X-ray imaging and quantification of the iron cellular architecture within single fibroblasts of Friedreich's ataxia patients

De Samber, B.; Vanden Berghe, T.; Meul, E.; Bauters, S.; Seyrich, M.; Smet, J.; De Paepe, B.; Silva, J. C. da; Bohic, S.; Cloetens, P.; Van Coster, R.; Vandenabeele, P.; Vincze, L.

doi:10.1107/S1600577519015510

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Figure 1
(a) XRF sum spectrum of AXO thin film standard (black curve), Si₃N₄ membrane of 500 nm thickness of `minatec test structure' (green curve), pressed pellet of NIST SRM 1577C (16.2 mg cm⁻², black curve), entire fibroblast shown in Fig. 4

(blue curve), iron hot-spot shown in Fig. 4(g)

. All spectra were normalized to 100 s measuring time, no absorbers and high-dose mode. (b) Relative detection limits of NIST SRM 1577C (bovine liver) and AXO thin film for experimental conditions typically used for cell scanning (high dose, no absorber, 50 ms dwell time).

JOURNAL OF
SYNCHROTRON
RADIATION

ISSN: 1600-5775

Volume 27| Part 1| January 2020| Pages 185-198

https://doi.org/10.1107/S1600577519015510

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