forthcoming articles

We develop and evaluate a deep learning-based algorithm that demonstrates the potential to reconstruct simultaneously high resolution, high frame-rate X-ray image sequences with high fidelity through spatio-temporal fusion. Our experimental evaluation shows that our method can significantly improve the accuracy of the reconstruction, achieving an average peak signal-to-noise ratio (PSNR) of more than 35 dB on two representative X-ray image sequences with input data streams of 4 times lower spatial resolution and 20 times lower frame rate, respectively.

An open-source software system for managing user office operations at a large-scale research facility is presented.

The SPXF has revolutionized structural biology research through its advanced light sources, enabling crucial breakthroughs in disease research. The facility's integration of automation and cutting-edge techniques provides world-class resources for global researchers.

We applied advanced image-processing techniques, including fast Fourier Transform analysis, image registration and optical flow, to mitigate artifacts caused by system instabilities and accurately track battery electrode deformations during operation. This approach improves the reliability of high-resolution operando imaging, providing deeper insights into battery degradation and enhancing our understanding of chemomechanical interactions in battery performance.

Structure-based drug design has been a critical component of drug discovery for over 30 years, contributing to numerous approved drugs. The paper discusses the approach taken by AstraZeneca (Sweden) to synchrotron data collection for supporting a large portfolio of drug discovery projects and provides examples to demonstrate the continued importance of experimental structures.

This controlled radiation damage study at different temperatures allows the approaches to measuring radiation-damage-free/limited spectra from redox-sensitive metalloenzymes and metal complexes in the soft X-ray regime at synchrotrons to be refined.

A new online beam intensity synchronous monitoring system has been designed which can precisely and synchronously monitor X-ray beam intensity variations. This can be used to remove noise due to electron injection from STXM images, thereby markedly improving the quality of STXM imaging.

A method for compensating for the source drift of a free-electron laser beamline by adjusting the C_ff value of a grating monochromator is introduced.

A timing control system to stabilize the long-term timing drift between X-ray free-electron laser (XFEL) and optical laser pulses has been developed by utilizing an out-of-loop balanced optical-microwave phase detector and an arrival-timing monitor. The timing jitter and drift between the XFEL and the optical laser pulses have been reduced to less than 50 fs (RMS) over ∼49 h.

We present the development of a novel fixed-target flip-holder for synchrotron serial crystallography. This holder simplifies the sample handling process, reduces dehydration risks, and enables efficient crystallography experiments with minimal sample consumption, demonstrated through successful lysozyme crystal structure determination at room temperature.