Structure of the effector-binding domain of the LysR-type transcription factor RovM from Yersinia pseudotuberculosis

The structure of the effector-binding domain of the LysR-type transcription regulator RovM from Y. pseudotuberculosis is reported at 2.4 Å resolution, showing a potential inducer-binding cavity.

Structure of PduT, a trimeric bacterial microcompartment protein with a 4Fe–4S cluster-binding site

The 1.86 Å resolution crystal structure of propanediol-utilization (Pdu) microcompartment shell protein PduT from the bacterium Citrobacter freundii is reported.

Structure of an RNA dimer of a regulatory element from human thymidylate synthase mRNA

An oligonucleotide representing a regulatory element of human thymidylate synthase mRNA has been crystallized as a dimer. The structure of the asymmetric dimer has been determined at 1.97 Å resolution.

The structure of TTHA0988 from Thermus thermophilus, a KipI–KipA homologue incorrectly annotated as an allophanate hydrolase

TTHA0988 from T. thermophilus represents a class of protein found almost ubiquitously across bacterial species which is incorrectly annotated as allophanate hydrolase. Three crystal forms of TTHA0988 have been solved which reveal the domain organization and range of motion within this protein family.

Structural and biochemical analyses of the human PAD4 variant encoded by a functional haplotype gene

In order to study the effects of three amino-acid substitutions found in PAD4^SNP, the crystal structure of PAD4^SNP has been determined.

Structural basis for the cyclophilin A binding affinity and immunosuppressive potency of E-ISA247 (voclosporin)

X-ray crystal structures of the cyclosporin A analogue E-ISA247 (voclosporin) and its stereoisomer Z-ISA247 bound to cyclophilin A suggest the molecular basis for the differences in their binding affinities and immunosuppressive efficacies.

Structure of the minor pseudopilin XcpW from the Pseudomonas aeruginosa type II secretion system

The structure of XcpW_J has been refined to 1.85 Å resolution and revealed a type IVa pilin fold with an embellished variable antiparallel β-sheet.

Crystal structure analysis of icosahedral lumazine synthase from Salmonella typhimurium, an antibacterial drug target

The structure of icosahedral lumazine synthase from S. typhimurium is reported at 3.57 Å resolution.

X-ray and neutron protein crystallographic analysis of the trypsin–BPTI complex

The crystal structure of the trypsin–bovine pancreatic trypsin inhibitor (BPTI) complex was refined using X-ray and neutron data. Both protonation states of the catalytic triad and H/D exchange of the amide H atom of P1′ Ala16 of the scissile peptide bond were observed in the trypsin–BPTI complex.