issue contents

ISSN: 2053-230X

July 2018 issue

Highlighted illustration

Cover illustration: Crystal structure of N-acetylmannosamine-6-phosphate 2-epimerase from Vibrio cholerae (Manjunath et al., p. 431). Studies on NanE from V. cholerae and Fusobacterium nucleatum have allowed an evaluation of whether NanE may be a good drug target against these pathogenic bacteria.

research communications

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Two different conformations, closed and open forms, of the E. coli poly-α-L-glutamate synthetase protein RimK were determined in complex with the ATP analogue AMP-PNP by X-ray crystallography at 2.05 Å resolution. The structure of the open form of RimK is unique and differs substantially from the structures of its homologues.

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The crystallization and structural analysis of the various players in the ataRT toxin–antitoxin module from enteropathogenic Escherichia coli are reported: the toxin AtaT, the intrinsically disordered antitoxin AtaR and its complex with a 22 bp fragment of the operator DNA.

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The three-dimensional structure of Escherichia coli purine nucleoside phosphorylase (PNP) complexed with acyclovir has been solved and a comparison with other complexes of PNP with guanosine derivatives has been carried out.

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A mobile application has been developed to facilitate the human annotation of crystallization images.

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The gene encoding a novel bacterial class V dye-decolourizing peroxidase (DyP) from the extremely radiation-resistant and desiccation-resistant bacterium Deinococcus radiodurans was cloned and optimum conditions for high-yield expression were identified. The optimized crystals diffracted to 2.2 Å resolution and the initial characterization and crystallographic analysis is promising with respect to providing highly desired insights into this largely unknown family of DyPs.

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The recombinant expression, purification, crystallization and crystal structure of human anterior gradient protein 3, a single-domain member of the protein disulfide isomerase family that lacks the canonical active-site motif, are described.

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