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August 2023 issue
Cover illustration: Crystal structure of Prp16 in complex with ADP [Garbers et al. (2023), Acta Cryst. F79, 200–207]. The DEAH-box helicase Prp16 plays a crucial role in pre-mRNA splicing and is the driving force during spliceosomal catalysis. Here, the first crystal structure of Prp16 from Chaetomium thermophilum in complex with ADP is reported at 1.9 Å resolution.
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Prp16 is a DEAH-box ATPase required for the splicing of pre-mRNA. The X-ray crystal structure of the Prp16-ADP complex was determined at a resolution of 1.9 Å.
PDB reference: Prp16, complex with ADP, 8cnt
The crystal structure of M. tuberculosis FadD23 complexed with the inhibitor 5′-O-[N-(11-phenoxyundecanoyl)sulfamoyl]adenosine was solved at 2.64 Å resolution and compared with similar three-dimensional structures. It is proposed that the inhibitor blocks substrate transfer from FadD23 to polyketide synthase 2.
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The 3D structure of a GCN5-related N-acetyltransferase enzyme that is selective for canavanine has been elucidated and shown to share the fold and catalytic mechanism of the polyamine acetyltransferase subclass.
PDB reference: LcGNAT, 8osp
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