Crystal structure of a short-chain dehydrogenase from Burkholderia cenocepacia J2315 in complex with NADP+ and benzoic acid

Belfon, K.K.J.; Beyer, O.; Abendroth, J.; Dranow, D.M.; Lorimer, D.D.; Abramov, A.; Latimore, Y.; Hamilton, C.; Dawkins, A.; Hinojosa, I.; Martinez, X.; Mirabel, S.; Duncan, M.; Womack, R.; Hicks, L.; Turlington, Z.R.; Edwards, T.E.; Torelli, A.T.; Hicks, K.A.; French, J.B.

doi:10.1107/S2053230X24011282

Acta Crystallographica Section F
Acta Crystallographica
Section F STRUCTURAL BIOLOGY COMMUNICATIONS

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Figure 1
SDR chemistry. SDRs are NAD(P)-dependent oxidoreductases that catalyse a wide range of reactions, including carbonyl–alcohol oxidoreductions as shown in (a). Most SDRs have some variation of a YxxxK active-site motif. The highly conserved tyrosine residue acts as the putative active-site base in the proposed SDR mechanism (b).

STRUCTURAL BIOLOGY
COMMUNICATIONS

ISSN: 2053-230X

Volume 80| Part 12| December 2024| Pages 348-355

https://doi.org/10.1107/S2053230X24011282

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