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Figure 1
SDR chemistry. SDRs are NAD(P)-dependent oxido­reductases that catalyse a wide range of reactions, including carbonyl–alcohol oxido­reductions as shown in (a). Most SDRs have some variation of a YxxxK active-site motif. The highly conserved tyrosine residue acts as the putative active-site base in the proposed SDR mechanism (b).

Journal logoSTRUCTURAL BIOLOGY
COMMUNICATIONS
ISSN: 2053-230X
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