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Figure 3
Comparison of tautomerase inhibitor-binding cavities in surface plots of hMIF-1 (cyan; PDB entry 1mif), AceMIF (purple; PDB entry 3rf4) and His-OvMIF-1 (gray). Furosemide (shown as sticks), a selective inhibitor of AceMIF, fits best into its larger cavity of AceMIF, hMIF has a smaller cavity and His-OvMIF-1 lacks the cavity (top row). The superposed trimer surfaces are shown in the bottom row. The structure of His-OvMIF-1 with the N-terminal tag in magenta is shown, as is the structure of OvMIF-1 generated by deleting the tag. OvMIF-1 has a more open cavity than the other structures.

Journal logoSTRUCTURAL BIOLOGY
COMMUNICATIONS
ISSN: 2053-230X
Volume 80| Part 12| December 2024| Pages 328-334
https://doi.org/10.1107/S2053230X24010550
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