Crystal structure of rice L-galactose de­hydrogenase

Crystal structures of rice L-galactose dehydrogenase in apo and NAD⁺-bound forms reveal a conserved architecture and flexible loop regions that are involved in cofactor and substrate binding.

Crystal structure of the NKX2-1 homeodomain bound to a palindromic DNA recognition sequence

The crystal structure of the NKX2-1 homeodomain bound to DNA reveals the arrangement of two homeodomains on a palindromic NK2-recognition sequence and provides insight into disease-associated variants.

Diverse DTPA-chelated lanthanides with relevance for nuclear medicine bound to an engineered lipocalin reveal conserved ligand geometry

Structural and binding studies of the engineered lipocalin CL31d towards the chelate complexes of 11 different lanthanide and main-group metal(III) ions, whose radioisotopes are useful for nuclear medicine, with a functionalized DTPA revealed a surprisingly broad tolerance towards varying ionic radii, thus enabling flexible radionuclide-targeting strategies.

Molecular insights into NLRP1 Gly/N-degron recognition by CRL2^ZER1

We present the ZER1–NLRP1 Gly/N-degron structure, revealing a conserved binding cavity for N-terminal glycine recognition. ZER1 binds more weakly than ZYG11B due to distinct interactions at position 3, providing mechanistic insights into NLRP1 inflammasome regulation.

Structural and functional analysis of peptidyl-tRNA hydrolase 2 from Candidatus Lokiarchaeum sp. GC14_75

The crystal structure of peptidyl-tRNA hydrolase 2 from Candidatus Lokiarchaeum sp. GC14_75 (LokiPth2) shows conformational rearrangements that may be associated with substrate recognition and catalysis. In addition, analysis of the optimal temperature for LokiPth2 activity suggests that this archaeon is a moderate thermophile.