issue contents
June 2016 issue
![Highlighted illustration](/f/issues/2016/06/00/graphics/coverill.gif)
Cover illustration: Structure of the I-SceI nuclease complexed with its dsDNA target and three catalytic metal ions (Prieto et al., p. 473). Homing endonucleases such as I-SceI are highly specific DNA-cleaving enzymes that recognize and cleave long stretches of DNA. The engineering of these enzymes provides instruments for genome modification in a wide range of fields, including gene targeting.
research communications
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