Crystal structure of (S)-3-O-geranylgeranylglyceryl phosphate synthase from Thermoplasma acidophilum in complex with the substrate sn-glycerol 1-phosphate

The first structure of (S)-3-O-geranylgeranylglyceryl phosphate synthase (GGGPS) from a thermoacidophilic archaeon, Thermoplasma acidophilum, with the substrate sn-glycerol 1-phosphate is described. Structural comparisons of this enzyme with other structurally determined archaeal GGGPS proteins are described.

Crystal structure of an iron superoxide dismutase from the pathogenic amoeba Acanthamoeba castellanii

The crystal structure of an iron superoxide dismutase from Acanthamoeba castellanii, a pathogenic amoeba, was determined at 2.33 Å resolution. It belonged to space group P6₁, with 12 molecules forming three tetramers in the asymmetric unit.

Structural characterization of Treponema pallidum Tp0225 reveals an unexpected leucine-rich repeat architecture

Phylogenetic and structural characterization of the only predicted leucine-rich repeat-containing protein from the human pathogen Treponema pallidum is reported.

Co-crystal structure of the Fusobacterium ulcerans ZTP riboswitch using an X-ray free-electron laser

An X-ray free-electron laser was used to determine the structure of the ZTP riboswitch, an RNA motif that is responsible for regulating gene expression in bacteria.

Crystal structure of the glycoside hydrolase PssZ from Listeria monocytogenes

The crystal structure of PssZ has been determined at 1.6 Å resolution. PssZ belongs to glycoside hydrolase family 8 and adopts a classical (α/α)₆-barrel fold.

Structural comparison of p-hydroxybenzoate hydroxylase (PobA) from Pseudomonas putida with PobA from other Pseudomonas spp. and other monooxygenases

p-Hydroxybenzoate hydroxylase (PobA) is a possible drug target to combat tetracycline resistance. Here, the 2.2 Å resolution structure of PobA from the pathogen Pseudomonas putida complexed with FAD is reported and is compared with those of PobA from P. aeruginosa and P. fluorescens.

A promiscuous kinase inhibitor delineates the conspicuous structural features of protein kinase CK2a1

The crystal structure of protein kinase CK2a1 in complex with 5-iodotubercidin, an ATP-analogue inhibitor, was determined at 1.78 Å resolution. This structure should facilitate the discovery of selective CK2a1 inhibitors.

Structural insights into the substrate specificity of SP_0149, the substrate-binding protein of a me­thionine ABC transporter from Streptococcus pneumoniae

This study reports the three-dimensional structure of the substrate binding of a methionine transporter from Streptococcus pneumoniae bound to methionine. The high-resolution structure provides atomic-level details of its substrate specificity.