issue contents

ISSN: 2053-230X

August 2019 issue

Highlighted illustration

Cover illustration: An inexpensive automated microscope (AMi) that has been specifically designed for viewing and imaging the contents of multi-well plates, and is controlled through the dedicated software AMiGUI [Bohm (2019), Acta Cryst. F75, 531-536].


link to html
A new category of Acta Crystallographica F articles, Methods Communications, is introduced. The first of these to be published, describing an inexpensive crystallization imaging system, is discussed here. Readers are also reminded about another category of articles, Topical Reviews, which are now defined.

methods communications

link to html
Described here are instructions for building and using an inexpensive automated microscope that is driven by a dedicated graphical user interface. The system facilitates the automated imaging and manual inspection of multi-well plates.

research communications

link to html
The isolation of the dominant isoform of haemoglobin from Atlantic cod caught in southwest Norway is reported and its X-ray crystal structure is presented.

link to html
Kallikrein-4 (KLK4) is a serine protease that is an attractive target for prostate cancer therapeutics. Here, the first crystal structure of catalytically active KLK4 in an uninhibited state is reported. The 1.64 Å resolution structure shows a canonical fold, but uses a nonstandard rotamer in a specificity-determining residue. This model will prove useful in understanding the subtle structural changes that are induced upon the binding of a ligand, and thus in the future structure-guided design of KLK4 inhibitors.

link to html
The iMango-III aptamer demonstrates one of the largest fluorescence enhancements of all RNA aptamers. Here, the room-temperature crystal structure of the iMango-III aptamer determined using an X-ray free-electron laser is reported.

link to html
A 1.7 Å resolution co-crystal structure of U7BR from Schizosaccharomyces pombe in complex with Ubc7 is reported. Structural comparisons and biochemistry suggest that U7BR presents a steric impediment to E1 binding and inhibits E1-mediated charging, respectively.

link to html
Crystallization and structural analysis are reported of the Rel stringent factor from Thermus thermophilus in the resting state and bound to nucleotides.
Follow Acta Cryst. F
Sign up for e-alerts
Follow Acta Cryst. on Twitter
Follow us on facebook
Sign up for RSS feeds