Crystal structures of anthranilate phosphoribosyltransferase from Saccharomyces cerevisiae

Structural comparison of the apo form of Saccharomyces cerevisiae anthranilate phosphoribosyltransferase with structures of its complexes with PRPP or the substrate analogue 4-fluoroanthranilate provide structural insights into substrate binding.

Crystal structure of human CRM1, covalently modified by 2-mercapto­ethanol on Cys528, in complex with RanGTP

The covalent modification of human CRM1 by 2-mercaptoethanol interferes with the characterization of cysteine-dependent inhibitor compounds.

Structural analysis of the Sulfolobus solfataricus TF55β chaperonin by cryo-electron microscopy

The isolated complex of the TF55β chaperonin from the thermophilic archaeon Sulfolobus solfataricus are reported. The structures of nucleotide-bound complexes of TF55β obtained at 3.6–4.2 Å resolution using cryo-EM reveal an open conformation.

Crystal structure of the nonclassical cadherin-17 N-terminus and implications for its adhesive binding mechanism

Cadherin-17, a 7D-cadherin, has N-terminal extracellular cadherin (EC) repeats similar to those of classical cadherins but with several key differences that are relevant to its biological function. The structure presented here demonstrates that cadherin-17 is incapable of forming the EC1 tryptophan-mediated strand-swap conformation that classical cadherins use to adhere cells together.