Delineating the activity of the potent nicotinic acetylcholine receptor agonists (+)-anatoxin-a and (−)-hosieine-A

The binding of two potent alkaloid neurotoxins to acetylcholine-binding protein was investigated using calorimetry and fluorescence titration. The crystal structures of two complexes and sequence and structure comparisons inform discussion on the biological implications for interactions with human nicotinic acetylcholine receptor subtypes, which are important therapeutic targets.

Crystallization and crystallographic studies of a novel chickpea 11S globulin

The first structural report of CL-AI from chickpea seeds reveals a trimeric arrangement and structural features that are conserved among 11S globulins.

Structure of angiogenin dimer bound to double-stranded RNA

Angiogenin is a pathologically relevant but little understood ribonuclease, the interactions of which with RNA are structurally unknown. Here, the first crystal structure of human angiogenin bound to RNA is presented.

Structure of the hypothetical protein TTHA1873 from Thermus thermophilus

The crystal structure of the hypothetical protein TTHA1873 from T. thermophilus has been determined using X-ray crystallography. At high concentrations, the protein showed visible agglutination of red blood cells; its structural properties and thermal stability are discussed.

Crystallization and preliminary X-ray analysis of the C-type lectin domain of the spicule matrix protein SM50 from Strongylocentrotus purpuratus. Corrigendum

The article by Juneja et al. [(2014), Acta Cryst. F70, 260–262] is corrected.