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December 2022 issue
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Cover illustration: The purine nucleoside phosphorylase from Geobacillus stearothermophilus is a thermostable protein of potential interest for the biocatalytic synthesis of antiviral nucleoside compounds. The structure of the protein was determined and found to include a His tag in the active site [Given et al. (2022), Acta Cryst. F78, 416–422]. This study shows that while tags are useful in the purification of proteins, we need to ensure that they do not have unwanted effects on protein structure and function.
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