Bacterial structural genomics target enabled by a recently discovered potent fungal acetyl-CoA synthetase inhibitor

Rescue efforts for acetyl-CoA synthetase (ACS) proteins in complex with ethyl-AMP yielded the first structure of ACS from L. pneumophila with a very well defined ethyl-AMP bound in the active site.

Crystal structure of a three-tetrad, parallel, K⁺-stabilized human telomeric G-quadruplex at 1.35 Å resolution

The crystal structure of the G-rich human telomeric DNA Tel22 has been determined at 1.35 Å resolution. The structure contains a three-tetrad parallel G-quadruplex (GQ) that forms a 5′–5′ dimer with a symmetry-generated molecule and is stabilized by five potassium ions. The solvent sphere contains polyethylene glycol, two potassium ions and 111 water molecules. The presence of polyethylene glycol is significant as it has been shown to stabilize the parallel GQ conformation, yet its mechanism of interaction with a parallel GQ is not fully understood.

Crystal structure of a putative 3-hydroxypimelyl-CoA de­hydrogenase, Hcd1, from Syntrophus aciditrophicus strain SB at 1.78 Å resolution

The crystal structure of a putative 3-hydroxypimelyl-CoA dehydrogenase from the model syntrophic bacterium S. aciditrophicus strain SB has been determined to a resolution of 1.78 Å. S. aciditrophicus strain SB degrades benzoate and alicyclic acids.

Crystal structure of thermostable acetaldehyde de­hydrogenase from the hyperthermophilic archaeon Sulfolobus tokodaii

Thermostable acetaldehyde dehydrogenase from S. tokodaii was prepared and its crystal structure was determined.