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Journal logoSTRUCTURAL
CHEMISTRY
ISSN: 2053-2296

April 2025 issue

Early view articles

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research papers


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There are very few examples of crystallographically well-documented racemic mimics. Therefore, this inter­esting class of crystalline mol­ecules, potentially having useful biological uses, is today one of those scientific orphans largely ignored in the crystallographic realm. Some suggestions are provided for searching for potential cases of such a crystallization mode using information already in print.

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The crystal structure of capsaicin, the natural product responsible for the pungency of chilli peppers, was determined by low-temperature single-crystal X-ray diffraction.

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The ability to control the yield for a [2+2] cyclo­addition photoreaction by using a mixed cocrystal approach is reported. The two isosteric halogen-bond donors allow for the formation of the cocrystal solid solution and as a result influences the extent of the photoreaction based upon their initial molar ratios.

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The biological activity of a newly synthesized py­rido[3,4-d]pyridazinone was investigated in terms of cytotoxic (on the normal cell lines L929 and RPTEC, as well as the cancer cell lines A172, AGS, CACO-2 and HepG2) and anti-inflammatory (using colorimetric assay for inhibition of COX-1 and COX-2) properties.

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The supra­molecular inter­actions and Hirshfeld surfaces of three multicom­ponent systems, namely, 2,4-di­amino-6-phenyl-1,3,5-tri­a­z­ine–nicotinic acid, 2,4-di­amino-6-phenyl-1,3,5-triazin-1-ium hy­dro­gen malonate and 2,4-di­amino-6-phenyl-1,3,5-triazin-1-ium hy­dro­gen (+)-dibenzoyl-D-tartarate have been investigated.

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Four novel benzyl­amine-based crown ether inclusion com­plexes have been synthesized, [(4-XBA)(18-crown-6)][DMSA] [X = F, Cl, Br and I; BA= benzyl­amine; DMSA = di(methane­sulfony)amidate]. The effects of the different halogen atoms on the stacking within the crystals of the com­plexes are described.

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8-Ethynyl-2′-de­oxy­iso­guano­sine exists as an organized mixture of the N1-H and N3-H tautomers in the solid state. The nu­cle­o­side is in a syn conformation, which is stabilized by hy­dro­gen bonds between the heterocycle and the sugar residue. A tridentate purine–purine base pair in the crystal packing is enabled by alteration of the donor–acceptor pattern of the nucleo­base due to tautomerism.

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The Barton–Kellogg olefination of a thio­benzo­phenone and a 3H-1,2-di­thiole-3-thione yields the corresponding alkenes, whose solid-state structures, along with that of an inter­mediate thiirane, have been characterized and found to be similar to those of related com­pounds.

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A com­parison of the structure of newly synthesized KHfF5 with other com­plex fluorides of alkali metals and hafnium, zirconium or terbium(IV) revealed that this com­pound has no isostructural analogue among the known phases of general com­position MIMIVF5.
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