Taking biological structure communications into the third dimension

The Editors of Acta Cryst. F describe a new feature that will add an extra dimension to the journal.

Automatic annotation of protein residues in published papers

An annotation tool is presented that automatically locates amino-acid residues in published papers and matches them to protein structures within the paper. These matches can be provided in context or in a searchable format in order for researchers to better use the existing and future literature.

Inexpensive robotic system for standard and fluorescent imaging of protein crystals

An open-source automated microscope capable of capturing both fluorescent and standard images from multi-well protein crystallization plates is described.

Major conformational changes in the structure of lysozyme obtained from a crystal with a very low solvent content

An alternately folded structure of orthorhombic lysozyme obtained from crystals grown at pH 5.5 with 26% solvent content is described.

Structural analysis of free and liganded forms of the Fab fragment of a high-affinity anti-cocaine antibody, h2E2

Ths structure of the Fab fragment of the high-affinity anti-cocaine antibody h2E2 is reported both as the free Fab and in complex with the cocaine metabolite benzoylecgonine.

The non-swapped monomeric structure of the arginine-binding protein from Thermotoga maritima

The crystal structure of the P235GK mutant of the arginine-binding protein from Thermotoga maritima in its monomeric state provides clues to the structural determinants of the domain swapping observed in the wild-type protein.

Conformational heterogeneity in apo and drug-bound structures of Toxoplasma gondii prolyl-tRNA synthetase

The apo-to-holo transition of an enzyme allows insights into the structural hinges that accommodate different ligands within its active site. Here, such a hinge is elucidated in Toxoplasma gondii prolyl-tRNA synthetase and shown in its different possible conformations in two apo forms and two inhibitor-bound forms.