The crystal structure of DynF from the dynemicin-biosynthesis pathway of Micromonospora chersina

The crystal structure of DynF was determined to a resolution of 1.50 Å, revealing a dimeric eight-stranded β-barrel structure with palmitic acid bound in the interior.

Cryotrapping peroxide in the active site of human mitochondrial manganese superoxide dismutase crystals for neutron diffraction

Human mitochondrial manganese superoxide dismutase (MnSOD) is a major player in alleviating oxidative stress within the mitochondria, which is a characteristic of a wide range of human diseases. Here, the methods leading to the structural visualization of the evasive peroxo complex of MnSOD by integrating cryotrapping and neutron protein crystallography are described.

X-ray structure of a human cardiac muscle troponin C/troponin I chimera in two crystal forms

The X-ray crystal structure of a human cardiac muscle troponin C/troponin I chimera has been determined in two different crystal forms and shows a conformation of the complex that differs from that previously observed by NMR. In contrast to previous models, the troponin I helix runs in a parallel direction relative to the troponin C groove and completely blocks the calcium desensitizer binding site of the troponin C–troponin I interface.

Crystal structure of a putative short-chain de­hydrogenase/reductase from Paraburkholderia xenovorans

The high-resolution structure of a putative short-chain reductase from the commercially important bacterium Paraburkholderia xenovorans is reported. P. xenovorans degrades organic wastes such as polychlorinated biphenyls.

Crystal structures of FolM alternative di­hydrofolate reductase 1 from Brucella suis and Brucella canis

Crystal structures of FolM alternative dihydrofolate reductase 1 from Brucella suis and Brucella canis reveal prototypical NADPH-dependent short-chain reductases with structural similarity to protozoan pteridine reductases that are potential drug targets.

Crystallization and low-resolution structure solution of the SALM3–PTPσ synaptic adhesion complex

The crystallization of the SALM3–PTPσ synaptic adhesion complex and the initial low-resolution structure solution by molecular replacement is presented. This independently verifies the architecture of the ligand complex to be similar to the SALM5–PTPδ crystal structure and complements our previous small-angle X-ray scattering studies.